Lipotris™

Liposomal intra-articular composite gel

Product parameters

44 mg in 2 ml
Sodium hyaluronate
1.6 mg in 2 ml
Liposomes
70-200 Pa·s
Viscosity
100%
Safe bacterial fermentation

Description

The Lipotris™ liposomal composite gel represents a new class of injectable products supporting joint function. Developed using the controlled manufacturing technology Lipotris Assembly Process (LAP™), it is characterized by an organized composite structure with predictable and reproducible rheological properties, as well as increased resistance to hydrolytic degradation.

Lipotris™ combines hyaluronic acid with phospholipid-based components. Experimental studies have shown that combinations of hyaluronic acid and phospholipids can reduce friction more effectively than either component alone. Current models of cartilage lubrication also highlight the synergistic interaction of hyaluronan, lubricin and phospholipids at the articular surface. These interactions contribute to the exceptionally low friction characteristic of articular cartilage and provide a scientific rationale for approaches aimed at supporting joint lubrication.

Clinical observations with the liposomal intra-articular gel demonstrated reductions in pain and improvements in functional outcomes during follow-up.

How it works

A liposomal composite gel
Lipotris™ combines hyaluronic acid with synthetic phospholipid liposomes, forming a consolidated composite gel designed to support joint lubrication and movement quality.
Synergy of action
Hyaluronic acid, phospholipids and lubricin act synergistically at the cartilage surface, supporting boundary lubrication and helping reduce friction.
Supports an ultra-low-friction joint environment
The combination of hyaluronic acid and phospholipids can reduce cartilage-surface friction, supporting the ultra-low-friction conditions associated with synovial joint lubrication.

Clinical benefits

Support in pain relief
Significant pain reduction was observed and maintained during follow-up.
Improved performance
Significant improvements in functional performance were observed during follow-up.
Sustained clinical benefit
WOMAC and functional improvements were maintained for at least 6 months.

Regain the natural movement

With changing the movement from sliding to rolling.

Science

Liposomes
Phospholipid structures that interact with HA to form a composite supporting joint lubrication.
Hyaluronic Acid
A key component of synovial fluid contributing to joint lubrication and boundary layer formation.
Lubricin
A cartilage-surface protein that interacts with the HA–liposome composite and supports low-friction lubrication.

Tribology of synovial joint

The synovial joint is a bearing-like structure created by four main elements: articular cartilage, subchondral bone, synovial membrane and synovial fluid, providing the expected, high performance motion in the musculoskeletal system.

To ensure a correct motion quality, articular cartilage together with synovial fluid need to create an ideal tribological system, ensuring extremely reduced friction and wear protection at low and high loads. This is ensured by an appropriate interaction between articular cartilage and synovial fluid, in particular between cartilage surface proteins and synovial components, including hyaluronan, proteoglycans, various proteins such as albumin, globulin, fibrinogen and collagen, as well as phospholipids such as phosphatidylcholine.

Tribosupplement mechanism of action

Forms an HA–liposome composite
Hyaluronic acid and phospholipid liposomes form a consolidated composite structure.
Supports cartilage lubrication
HA and phospholipids contribute to highly effective boundary lubrication.
Supports a shift toward rolling-like motion
Liposomes can act as molecular roller bearings between cartilage surfaces, supporting rolling-like motion and low friction.
Supports smooth, low-friction movement
Enhanced boundary lubrication supports favorable tribological conditions for joint motion.

Resources

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Lipotris™

Product parameters

Description

How it works

A liposomal composite gel

Synergy of action

Supports an ultra-low-friction joint environment

Clinical benefits

Support in pain relief

Improved performance

Sustained clinical benefit

Regain the natural movement

Science

Liposomes

Hyaluronic Acid

Lubricin

Tribology of synovial joint

Tribosupplement mechanism of action

Forms an HA–liposome composite

Supports cartilage lubrication

Supports a shift toward rolling-like motion

Supports smooth, low-friction movement

Resources

Core Product Information

Patient Education

Videos

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References