Xerthra™ PRP kit

PRP is a concentrated fraction of peripheral blood containing a high number of platelets, which act as a natural source of biologically active molecules and growth factors.53, 60, 61

Once delivered to the target tissue, platelet-derived growth factors provide molecular signals involved in the response to injury and tissue damage.1 More than 300 biologically active molecules have been identified in the platelet secretome.53, 61

These factors can help modulate inflammation by inhibiting the production of pro-inflammatory cytokines such as IL-6 and IL-8.54 They also support extracellular matrix production, including aggrecan, type II collagen and hyaluronic acid in cartilage, and type I and III collagen in tendon tissue.5

PRP-derived growth factors can additionally stimulate the migration and proliferation of tendon and cartilage progenitor cells.62

Together, these processes contribute to restoring tissue homeostasis, supporting regeneration and reducing degradation processes in osteoarthritis-affected joints and tendinopathy.54, 55, 62, 63, 64

PRP quality matters

The biological potential of platelet-rich plasma (PRP) depends on the composition of the final preparation, including the concentration and total dose of platelets, releasing growth factors and other bioactive mediators involved in tissue repair processes.69

A platelet concentration of approximately ≥1 × 10⁶ platelets/µL has historically been proposed as a benchmark for therapeutically relevant PRP.70

However, contemporary evidence indicates that PRP quality should not be defined by platelet concentration alone. The final biological profile is also influenced by the preparation method and the presence of other cellular and plasma components.70